Enhanced antitumor efficacy, proliferative capacity, and alleviation of T cell exhaustion by fifth-generation chimeric antigen receptor T cells targeting B cell maturation antigen in multiple myeloma

Enhanced antitumor efficacy, proliferative capacity, and alleviation of T cell exhaustion by fifth-generation chimeric antigen receptor T cells targeting B cell maturation antigen in multiple myeloma

Chimeric antigen receptor (CAR) T cell therapy targeting B cell maturation antigen (BCMA) has been approved for treating multiple myeloma (MM). Some clinical studies reported suboptimal outcomes, including reduced cytotoxicity of CAR-T cells and tumor evasion through increased expression of programm...

Full description

Bibliographic Details
Main Authors: Pornpimon Yuti, Nunghathai Sawasdee, Krissada Natungnuy, Punchita Rujirachaivej, Piriya Luangwattananun, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Multiple myeloma
BCMA
Chimeric antigen receptor
CAR
Anti-PD-L1 scFv
Immune checkpoint blockade
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223014890

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223014890

Similar Items