Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing

RNA polymerase II (Pol II) pausing is a general regulatory step in transcription, yet the stability of paused Pol II varies widely between genes. Although paused Pol II stability correlates with core promoter elements, the contribution of individual sequences remains unclear, in part because no rapi...

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Bibliographic Details
Main Authors: Wanqing Shao, Sergio G-M Alcantara, Julia Zeitlinger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/41461