Improving the efficiency of homologous recombination by chemical and biological approaches in Yarrowia lipolytica.

Improving the efficiency of homologous recombination by chemical and biological approaches in Yarrowia lipolytica.

Gene targeting is a challenge in Yarrowia lipolytica (Y. lipolytica) where non-homologous end-joining (NHEJ) is predominant over homologous recombination (HR). To improve the frequency and efficiency of HR in Y. lipolytica, the ku70 gene responsible for a double stand break (DSB) repair in the NHEJ...

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Bibliographic Details
Main Authors: In-Seung Jang, Byung Jo Yu, Ji Yeon Jang, Jonggeon Jegal, Ju Young Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5864075?pdf=render

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http://europepmc.org/articles/PMC5864075?pdf=render

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