Structure-Based Identification of Natural-Product-Derived Compounds with Potential to Inhibit HIV-1 Entry

Structure-Based Identification of Natural-Product-Derived Compounds with Potential to Inhibit HIV-1 Entry

Broadly neutralizing antibodies (bNAbs) are potent in neutralizing a wide range of HIV strains. VRC01 is a CD4-binding-site (CD4-bs) class of bNAbs that binds to the conserved CD4-binding region of HIV-1 envelope (env) protein. Natural products that mimic VRC01 bNAbs by interacting with the conserve...

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Bibliographic Details
Main Authors: Nneka Ugwu-Korie, Osbourne Quaye, Edward Wright, Sylvester Languon, Odame Agyapong, Emmanuel Broni, Yash Gupta, Prakasha Kempaiah, Samuel K. Kwofie
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
HIV-1 entry
inhibition
CD4-binding site
VRC01
gp120
virtual screening
Online Access:https://www.mdpi.com/1420-3049/28/2/474

Internet

https://www.mdpi.com/1420-3049/28/2/474

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