RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling

RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling

Activation of CD40-signaling contributes to the initiation, progression and drug resistance of B cell lymphomas. We contributed to this knowledge by showing that constitutive CD40-signaling in B cells induces B cell hyperplasia and finally B cell lymphoma development in transgenic mice. CD40 activat...

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Bibliographic Details
Main Authors: Laura B. Kuhn, Stefanie Valentin, Kristina Stojanovic, Daniel C. Strobl, Tea Babushku, Yan Wang, Ursula Rambold, Laura Scheffler, Sonja Grath, Dorothy John-Robbert, Helmut Blum, Annette Feuchtinger, Andreas Blutke, Falk Weih, Daisuke Kitamura, Roland Rad, Lothar J. Strobl, Ursula Zimber-Strobl
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
CD40
non-canonical NF-ĸB-signaling
RelB
IL9R
transgenic mice
B cell lymphoma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.913275/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.913275/full

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