A novel bladder cancer - specific oncolytic adenovirus by CD46 and its effect combined with cisplatin against cancer cells of CAR negative expression

A novel bladder cancer - specific oncolytic adenovirus by CD46 and its effect combined with cisplatin against cancer cells of CAR negative expression

Abstract Background Conditionally replicative oncolytic adenoviruses (CRAds) display significant anti-tumor effects. However, the traditional adenovirus of serotype 5 (Ad5) entering cancer cells via coxsackie virus and adenovirus receptor (CAR) can’t be utilized for bladder cancer with low expressio...

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Bibliographic Details
Main Authors: Wenjuan Cao, Junqiang Tian, Chong Li, Yanjun Gao, Xingchen Liu, Jianzhong Lu, Yuhan Wang, Zhiping Wang, Robert S. Svatek, Ronald Rodriguez
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Virology Journal
Subjects:
Oncolytic adenoviruses
Bladder cancer
Coxsackie virus and adenovirus receptor
Cisplatin
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12985-017-0818-1

Internet

http://link.springer.com/article/10.1186/s12985-017-0818-1

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