mTOR inhibition improves the immunomodulatory properties of human bone marrow mesenchymal stem cells by inducing COX-2 and PGE2

mTOR inhibition improves the immunomodulatory properties of human bone marrow mesenchymal stem cells by inducing COX-2 and PGE2

Abstract Background Bone marrow mesenchymal stem cells (MSCs) are promising candidates for the treatment of various inflammatory disorders due to their profound immunomodulatory properties. However, the immunosuppressive capacity of MSCs needs activation by an inflammatory microenvironment, which ma...

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Bibliographic Details
Main Authors: Binsheng Wang, Yu Lin, Yongxian Hu, Wei Shan, Senquan Liu, Yulin Xu, Hao Zhang, Shuyang Cai, Xiaohong Yu, Zhen Cai, He Huang
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Immunosuppressive properties
Immunogenicity
TSC-mTOR pathway
Rapamycin
Online Access:http://link.springer.com/article/10.1186/s13287-017-0744-6

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http://link.springer.com/article/10.1186/s13287-017-0744-6

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