Deaggregation and Crystallization Inhibition by Small Amount of Polymer Addition for a Co-Amorphous Curcumin-Magnolol System

Deaggregation and Crystallization Inhibition by Small Amount of Polymer Addition for a Co-Amorphous Curcumin-Magnolol System

Different from previously reported co-amorphous systems, a co-amorphous curcumin-magnolol (CUR-MAG CM) system, as compared with its crystalline counterparts, exhibited decreased dissolution due to its aggregation during dissolution. The main purpose of the present study is to deaggregate CUR-MAG CM...

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Bibliographic Details
Main Authors: Jiawei Han, Luyuan Li, Meiling Su, Weili Heng, Yuanfeng Wei, Yuan Gao, Shuai Qian
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
curcumin
magnolol
co-amorphous
deaggregation
dissolution
physical stability
Online Access:https://www.mdpi.com/1999-4923/13/10/1725

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https://www.mdpi.com/1999-4923/13/10/1725

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