Glucocorticoid enhances presenilin1-dependent Aβ production at ER’s mitochondrial-associated membrane by downregulating Rer1 in neuronal cells

Glucocorticoid enhances presenilin1-dependent Aβ production at ER’s mitochondrial-associated membrane by downregulating Rer1 in neuronal cells

Stress-induced release of glucocorticoid is an important amyloidogenic factor that upregulates amyloid precursor protein (APP) and β secretase 1 (BACE1) levels. Glucocorticoid also contributes to the pathogenesis of Alzheimer’s disease (AD) by increasing ER-mitochondria connectivity, in which amyloi...

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Bibliographic Details
Main Authors: Gee Euhn Choi, Ji Yong Park, Mo Ran Park, Jee Hyeon Yoon, Ho Jae Han
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Redox Biology
Subjects:
Glucocorticoid
Alzheimer’s disease
Aβ
MAM
Presenilin
Rer1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002227

Internet

http://www.sciencedirect.com/science/article/pii/S2213231723002227

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