Pharmacological Stimulation of Soluble Guanylate Cyclase Counteracts the Profibrotic Activation of Human Conjunctival Fibroblasts

Pharmacological Stimulation of Soluble Guanylate Cyclase Counteracts the Profibrotic Activation of Human Conjunctival Fibroblasts

Conjunctival fibrosis is a serious clinical concern implicated in a wide spectrum of eye diseases, including outcomes of surgery for pterygium and glaucoma. It is mainly driven by chronic inflammation that stimulates conjunctival fibroblasts to differentiate into myofibroblasts over time, leading to...

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Bibliographic Details
Main Authors: Bianca Saveria Fioretto, Irene Rosa, Elena Andreucci, Rita Mencucci, Mirca Marini, Eloisa Romano, Mirko Manetti
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
conjunctival fibroblasts
myofibroblasts
conjunctival fibrosis
TGFβ1
soluble guanylate cyclase stimulation
Online Access:https://www.mdpi.com/2073-4409/13/4/360

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https://www.mdpi.com/2073-4409/13/4/360

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