Emodin alleviates hypertrophic scar formation by suppressing macrophage polarization and inhibiting the Notch and TGF-β pathways in macrophages

Emodin alleviates hypertrophic scar formation by suppressing macrophage polarization and inhibiting the Notch and TGF-β pathways in macrophages

Hypertrophic scar (HS) formation is a common complication that develops after skin injury; however, there are few effective and specific therapeutic approaches for HS. Emodin has previously been reported to inhibit mechanical stress-induced HS inflammation. Here, we investigated the molecular mechan...

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Bibliographic Details
Main Authors: Zihuan Xia, Jiancheng Wang, Songlin Yang, Cheng Liu, Shu Qin, Wenbo Li, Yulong Cheng, Huan Hu, Jin Qian, Yi Liu, Chenliang Deng
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2021-07-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Hypertrophic scar
Macrophage polarization
Emodin
Notch signaling
TGF-β signaling
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000800614&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000800614&tlng=en

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