Sleep/Wake Behavior and EEG Signatures of the TgF344-AD Rat Model at the Prodromal Stage

Sleep/Wake Behavior and EEG Signatures of the TgF344-AD Rat Model at the Prodromal Stage

Transgenic modification of the two most common genes (APPsw, PS1ΔE9) related to familial Alzheimer’s disease (AD) in rats has produced a rodent model that develops pathognomonic signs of AD without genetic tau-protein modification. We used 17-month-old AD rats (<i>n</i> = 8) and age-matc...

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Bibliographic Details
Main Authors: Matthias Kreuzer, Glenda L. Keating, Thomas Fenzl, Lorenz Härtner, Christopher G. Sinon, Ihab Hajjar, Vincent Ciavatta, David B. Rye, Paul S. García
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s
electroencephalography
sleep architecture
Online Access:https://www.mdpi.com/1422-0067/21/23/9290

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https://www.mdpi.com/1422-0067/21/23/9290

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