Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation
Haptens are small molecules that only elicit an immune response when bound to proteins. Haptens initially bind to self-proteins and activate innate immune responses by complex mechanisms via inflammatory cytokines and damage-associated molecular patterns and the subsequent upregulation of costimulat...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-01-01
|
Series: | Biology |
Subjects: | |
Online Access: | https://www.mdpi.com/2079-7737/12/1/123 |
_version_ | 1797445802705027072 |
---|---|
author | Eri Sakamoto Yasuhiro Katahira Izuru Mizoguchi Aruma Watanabe Yuma Furusaka Ami Sekine Miu Yamagishi Jukito Sonoda Satomi Miyakawa Shinya Inoue Hideaki Hasegawa Kazuyuki Yo Fumiya Yamaji Akemi Toyoda Takayuki Yoshimoto |
author_facet | Eri Sakamoto Yasuhiro Katahira Izuru Mizoguchi Aruma Watanabe Yuma Furusaka Ami Sekine Miu Yamagishi Jukito Sonoda Satomi Miyakawa Shinya Inoue Hideaki Hasegawa Kazuyuki Yo Fumiya Yamaji Akemi Toyoda Takayuki Yoshimoto |
author_sort | Eri Sakamoto |
collection | DOAJ |
description | Haptens are small molecules that only elicit an immune response when bound to proteins. Haptens initially bind to self-proteins and activate innate immune responses by complex mechanisms via inflammatory cytokines and damage-associated molecular patterns and the subsequent upregulation of costimulatory signals such as cluster of differentiation 86 (CD86) on dendritic cells. Subsequent interactions between CD86 and CD28 on T cells are critically important for properly activating naive T cells and inducing interleukin 2 production, leading to the establishment of adaptive immunity via effector and memory T cells. Accumulating evidence revealed the involvement of haptens in the development of various autoimmune-like diseases such as allergic, inflammatory, and autoimmune diseases including allergic contact dermatitis, atopy, asthma, food allergy, inflammatory bowel diseases, hemolytic anemia, liver injury, leukoderma, and even antitumor immunity. Therefore, the development of in vitro testing alternatives to evaluate in advance whether a substance might lead to the development of these diseases is highly desirable. This review summarizes and discusses recent advances in chemical- and drug-induced allergic, inflammatory, and autoimmune diseases via haptenation and the possible molecular underlying mechanisms, as well as in vitro testing alternatives to evaluate in advance whether a substance might cause the development of these diseases. |
first_indexed | 2024-03-09T13:31:06Z |
format | Article |
id | doaj.art-54dce7ee5a3b4fbe9e89789209677a72 |
institution | Directory Open Access Journal |
issn | 2079-7737 |
language | English |
last_indexed | 2024-03-09T13:31:06Z |
publishDate | 2023-01-01 |
publisher | MDPI AG |
record_format | Article |
series | Biology |
spelling | doaj.art-54dce7ee5a3b4fbe9e89789209677a722023-11-30T21:17:43ZengMDPI AGBiology2079-77372023-01-0112112310.3390/biology12010123Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via HaptenationEri Sakamoto0Yasuhiro Katahira1Izuru Mizoguchi2Aruma Watanabe3Yuma Furusaka4Ami Sekine5Miu Yamagishi6Jukito Sonoda7Satomi Miyakawa8Shinya Inoue9Hideaki Hasegawa10Kazuyuki Yo11Fumiya Yamaji12Akemi Toyoda13Takayuki Yoshimoto14Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanPOLA Chemical Industries, Inc., 560 Kashio-cho, Totsuka-ku, Yokohama-shi 244-0812, Kanagawa, JapanPOLA Chemical Industries, Inc., 560 Kashio-cho, Totsuka-ku, Yokohama-shi 244-0812, Kanagawa, JapanPOLA Chemical Industries, Inc., 560 Kashio-cho, Totsuka-ku, Yokohama-shi 244-0812, Kanagawa, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanHaptens are small molecules that only elicit an immune response when bound to proteins. Haptens initially bind to self-proteins and activate innate immune responses by complex mechanisms via inflammatory cytokines and damage-associated molecular patterns and the subsequent upregulation of costimulatory signals such as cluster of differentiation 86 (CD86) on dendritic cells. Subsequent interactions between CD86 and CD28 on T cells are critically important for properly activating naive T cells and inducing interleukin 2 production, leading to the establishment of adaptive immunity via effector and memory T cells. Accumulating evidence revealed the involvement of haptens in the development of various autoimmune-like diseases such as allergic, inflammatory, and autoimmune diseases including allergic contact dermatitis, atopy, asthma, food allergy, inflammatory bowel diseases, hemolytic anemia, liver injury, leukoderma, and even antitumor immunity. Therefore, the development of in vitro testing alternatives to evaluate in advance whether a substance might lead to the development of these diseases is highly desirable. This review summarizes and discusses recent advances in chemical- and drug-induced allergic, inflammatory, and autoimmune diseases via haptenation and the possible molecular underlying mechanisms, as well as in vitro testing alternatives to evaluate in advance whether a substance might cause the development of these diseases.https://www.mdpi.com/2079-7737/12/1/123haptenpro-haptensallergic diseaseautoimmune diseaseinflammatory diseasesensitization |
spellingShingle | Eri Sakamoto Yasuhiro Katahira Izuru Mizoguchi Aruma Watanabe Yuma Furusaka Ami Sekine Miu Yamagishi Jukito Sonoda Satomi Miyakawa Shinya Inoue Hideaki Hasegawa Kazuyuki Yo Fumiya Yamaji Akemi Toyoda Takayuki Yoshimoto Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation Biology hapten pro-haptens allergic disease autoimmune disease inflammatory disease sensitization |
title | Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation |
title_full | Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation |
title_fullStr | Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation |
title_full_unstemmed | Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation |
title_short | Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation |
title_sort | chemical and drug induced allergic inflammatory and autoimmune diseases via haptenation |
topic | hapten pro-haptens allergic disease autoimmune disease inflammatory disease sensitization |
url | https://www.mdpi.com/2079-7737/12/1/123 |
work_keys_str_mv | AT erisakamoto chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT yasuhirokatahira chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT izurumizoguchi chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT arumawatanabe chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT yumafurusaka chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT amisekine chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT miuyamagishi chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT jukitosonoda chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT satomimiyakawa chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT shinyainoue chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT hideakihasegawa chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT kazuyukiyo chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT fumiyayamaji chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT akemitoyoda chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation AT takayukiyoshimoto chemicalanddruginducedallergicinflammatoryandautoimmunediseasesviahaptenation |