Conformational Dynamics of Human ALKBH2 Dioxygenase in the Course of DNA Repair as Revealed by Stopped-Flow Fluorescence Spectroscopy

Conformational Dynamics of Human ALKBH2 Dioxygenase in the Course of DNA Repair as Revealed by Stopped-Flow Fluorescence Spectroscopy

Elucidation of physicochemical mechanisms of enzymatic processes is one of the main tasks of modern biology. High efficiency and selectivity of enzymatic catalysis are mostly ensured by conformational dynamics of enzymes and substrates. Here, we applied a stopped-flow kinetic analysis based on fluor...

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Bibliographic Details
Main Authors: Lyubov Yu. Kanazhevskaya, Denis A. Smyshliaev, Nadezhda A. Timofeyeva, Alexander A. Ishchenko, Murat Saparbaev, Nikita A. Kuznetsov, Olga S. Fedorova
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
DNA repair
dioxygenase ALKBH2
DNA methylation
conformational dynamics
fluorescent spectroscopy
pre-steady-state kinetics
Online Access:https://www.mdpi.com/1420-3049/27/15/4960

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https://www.mdpi.com/1420-3049/27/15/4960

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