A loss of function analysis of host factors influencing Vaccinia virus replication by RNA interference.

A loss of function analysis of host factors influencing Vaccinia virus replication by RNA interference.

Vaccinia virus (VACV) is a large, cytoplasmic, double-stranded DNA virus that requires complex interactions with host proteins in order to replicate. To explore these interactions a functional high throughput small interfering RNA (siRNA) screen targeting 6719 druggable cellular genes was undertaken...

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Bibliographic Details
Main Authors: Philippa M Beard, Samantha J Griffiths, Orland Gonzalez, Ismar R Haga, Tali Pechenick Jowers, Danielle K Reynolds, Jan Wildenhain, Hille Tekotte, Manfred Auer, Mike Tyers, Peter Ghazal, Ralf Zimmer, Jürgen Haas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4047015?pdf=render

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http://europepmc.org/articles/PMC4047015?pdf=render

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