Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models

Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models

Recent advances in cancer treatment with checkpoint blockade of receptors such as CTLA-4 and PD-1 have demonstrated that combinations of agents with complementary immunomodulatory effects have the potential to enhance antitumor activity as compared to single agents. We investigated the efficacy of i...

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Bibliographic Details
Main Authors: Katherine E. Lewis, Mark J. Selby, Gregg Masters, Jose Valle, Gennaro Dito, Wendy R. Curtis, Richard Garcia, Kathy A. Mink, Kimberly S. Waggie, Matthew S. Holdren, Joseph F. Grosso, Alan J. Korman, Maria Jure-Kunkel, Stacey R. Dillon
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:OncoImmunology
Subjects:
interleukin 21
il-21
pd-1
ctla-4
mc38
ct26
emt-6
b16-f10
mouse tumor models
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1377873

Internet

http://dx.doi.org/10.1080/2162402X.2017.1377873

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