Complement Activation Contributes to the Pathophysiology of Shiga Toxin-Associated Hemolytic Uremic Syndrome

Complement Activation Contributes to the Pathophysiology of Shiga Toxin-Associated Hemolytic Uremic Syndrome

Shiga toxin (Stx)-producing Escherichia coli (STEC) infections have become a threat to public health globally because of the severe illnesses that they can trigger, such as hemorrhagic colitis and the post-diarrheal hemolytic uremic syndrome (HUS), characterized by microangiopathic hemolytic anemia,...

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Bibliographic Details
Main Authors: Simona Buelli, Carlamaria Zoja, Giuseppe Remuzzi, Marina Morigi
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Microorganisms
Subjects:
Shiga toxin
hemolytic uremic syndrome
endothelial damage
microvascular thrombosis
podocytes
complement alternative pathway
long-term renal sequelae
Online Access:http://www.mdpi.com/2076-2607/7/1/15

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http://www.mdpi.com/2076-2607/7/1/15

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