Development of Clinical Weekly-Dose Teriparatide Acetate Encapsulated Dissolving Microneedle Patch for Efficient Treatment of Osteoporosis

Development of Clinical Weekly-Dose Teriparatide Acetate Encapsulated Dissolving Microneedle Patch for Efficient Treatment of Osteoporosis

Teriparatide acetate (TA), which directly promotes bone formation, is subcutaneously injected to treat osteoporosis. In this study, TA with a once-weekly administration regimen was loaded on dissolving microneedles (DMNs) to effectively deliver it to the systemic circulation via the transdermal rout...

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Bibliographic Details
Main Authors: Jeeho Sim, Geonwoo Kang, Huisuk Yang, Mingyu Jang, Youseong Kim, Hyeri Ahn, Minkyung Kim, Hyungil Jung
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Polymers
Subjects:
osteoporosis
dissolving microneedle
teriparatide acetate
trehalose
centrifugal lithography
pharmacokinetic profile
Online Access:https://www.mdpi.com/2073-4360/14/19/4027

Internet

https://www.mdpi.com/2073-4360/14/19/4027

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