Proteomic Analysis of Dupuytren’s Contracture-Derived Sweat Glands Revealed the Synthesis of Connective Tissue Growth Factor and Initiation of Epithelial-Mesenchymal Transition as Major Pathogenetic Events

Proteomic Analysis of Dupuytren’s Contracture-Derived Sweat Glands Revealed the Synthesis of Connective Tissue Growth Factor and Initiation of Epithelial-Mesenchymal Transition as Major Pathogenetic Events

Dupuytren’s contracture (DC) is a chronic and progressive fibroproliferative disorder restricted to the palmar fascia of the hands. Previously, we discovered the presence of high levels of connective tissue growth factor in sweat glands in the vicinity of DC nodules and hypothesized that sweat gland...

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Bibliographic Details
Main Authors: Claudia Griselda Cárdenas-León, Kristina Mäemets-Allas, Mariliis Klaas, Katre Maasalu, Viljar Jaks
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
Dupuytren’s contracture
sweat gland
CTGF
E-cadherin
epithelial-mesenchymal transition
extracellular matrix
Online Access:https://www.mdpi.com/1422-0067/24/2/1081

Internet

https://www.mdpi.com/1422-0067/24/2/1081

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