Maturation of GABAergic Transmission in Cerebellar Purkinje Cells Is Sex Dependent and Altered in the Valproate Model of Autism

Maturation of GABAergic Transmission in Cerebellar Purkinje Cells Is Sex Dependent and Altered in the Valproate Model of Autism

Brain development is accompanied by a shift in gamma-aminobutyric acid (GABA) response from depolarizing-excitatory to hyperpolarizing-inhibitory, due to a reduction of intracellular chloride concentration. This sequence is delayed in Autism Spectrum Disorders (ASD). We now report a similar alterati...

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Bibliographic Details
Main Authors: Sébastien Roux, Ann Lohof, Yehezkel Ben-Ari, Bernard Poulain, Jean-Louis Bossu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cerebellum
Purkinje neuron
chloride gradient
autism
sexual dimorphism
GABAA channels
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00232/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00232/full

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