Structural determinants of peptide-dependent TAP1-TAP2 transit passage targeted by viral proteins and altered by cancer-associated mutations

Structural determinants of peptide-dependent TAP1-TAP2 transit passage targeted by viral proteins and altered by cancer-associated mutations

The TAP1-TAP2 complex transports antigenic peptide substrates into the endoplasmic reticulum (ER). In ER, the peptides are further processed and loaded on the major histocompatibility class (MHC) I molecules by the peptide loading complex (PLC). The TAP transporters are linked with the PLC; a target...

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Bibliographic Details
Main Authors: Monikaben Padariya, Sachin Kote, Marcos Mayordomo, Irena Dapic, Javier Alfaro, Ted Hupp, Robin Fahraeus, Umesh Kalathiya
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Peptide
Transporters
MHC-I
Cancer mutations
Viral factors
Molecular dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021003913

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http://www.sciencedirect.com/science/article/pii/S2001037021003913

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