High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells

High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells

BackgroundLong-term immunity to SARS-CoV-2 infection, including neutralizing antibodies and T cell-mediated immunity, is required in a very large majority of the population in order to reduce ongoing disease burden.MethodsWe have investigated the association between memory CD4 and CD8 T cells and le...

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Bibliographic Details
Main Authors: Chansavath Phetsouphanh, Weng Hua Khoo, Katherine Jackson, Vera Klemm, Annett Howe, Anupriya Aggarwal, Anouschka Akerman, Vanessa Milogiannakis, Alberto Ospina Stella, Romain Rouet, Peter Schofield, Megan L. Faulks, Hannah Law, Thidarat Danwilai, Mitchell Starr, C. Mee Ling Munier, Daniel Christ, Mandeep Singh, Peter I. Croucher, Fabienne Brilot-Turville, Stuart Turville, Tri Giang Phan, Gregory J. Dore, David Darley, Philip Cunningham, Gail V. Matthews, Anthony D. Kelleher, John J. Zaunders
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
neutralizing antibodies
CD4 T cells
CD4 function
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032911/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032911/full

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