CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways

CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways

Abstract Background The ischemia–reperfusion (IR) environment during deep hypothermic circulatory arrest (DHCA) cardiovascular surgery is a major cause of acute kidney injury (AKI), which lacks preventive measure and treatment. It was reported that cold inducible RNA-binding protein (CIRP) can be in...

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Bibliographic Details
Main Authors: Peiyao Zhang, Liting Bai, Yuanyuan Tong, Shengwen Guo, Wenlong Lu, Yue Yuan, Wenting Wang, Yu Jin, Peng Gao, Jinping Liu
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Molecular Medicine
Subjects:
Cold inducible RNA-binding protein
Ischemia–reperfusion
Renoprotection
Deep hypothermic circulatory arrest
Apoptosis
Reactive oxygen species
Online Access:https://doi.org/10.1186/s10020-023-00655-0

Internet

https://doi.org/10.1186/s10020-023-00655-0

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