Role of Glutathione in Buffering Excess Intracellular Copper in <italic toggle="yes">Streptococcus pyogenes</italic>

Role of Glutathione in Buffering Excess Intracellular Copper in <italic toggle="yes">Streptococcus pyogenes</italic>

ABSTRACT Copper (Cu) is an essential metal for bacterial physiology but in excess it is bacteriotoxic. To limit Cu levels in the cytoplasm, most bacteria possess a transcriptionally responsive system for Cu export. In the Gram-positive human pathogen Streptococcus pyogenes (group A Streptococcus [GA...

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Bibliographic Details
Main Authors: Louisa J. Stewart, Cheryl-lynn Y. Ong, May M. Zhang, Stephan Brouwer, Liam McIntyre, Mark R. Davies, Mark J. Walker, Alastair G. McEwan, Kevin J. Waldron, Karrera Y. Djoko
Format: Article
Language:English
Published: American Society for Microbiology 2020-12-01
Series:mBio
Subjects:
copper homeostasis
copper export
metal buffer
glutathione
group A Streptococcus
copper stress
Online Access:https://journals.asm.org/doi/10.1128/mBio.02804-20

Internet

https://journals.asm.org/doi/10.1128/mBio.02804-20

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