Analysis of proteasomal proteolysis during the in vitro metacyclogenesis of Trypanosoma cruzi.

Analysis of proteasomal proteolysis during the in vitro metacyclogenesis of Trypanosoma cruzi.

Proteasomes are large protein complexes, whose main function is to degrade unnecessary or damaged proteins. The inhibition of proteasome activity in Trypanosoma cruzi blocks parasite replication and cellular differentiation. We demonstrate that proteasome-dependent proteolysis occurs during the cell...

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Bibliographic Details
Main Authors: Josiane Cardoso, Carla De Paula Lima, Tiago Leal, Daniela F Gradia, Stênio P Fragoso, Samuel Goldenberg, Renata Guerra De Sá, Marco A Krieger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3117861?pdf=render

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http://europepmc.org/articles/PMC3117861?pdf=render

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