SCFAs switch stem cell fate through HDAC inhibition to improve barrier integrity in 3D intestinal organoids from patients with obesity

SCFAs switch stem cell fate through HDAC inhibition to improve barrier integrity in 3D intestinal organoids from patients with obesity

Summary: Stem cells are a keystone of intestinal homeostasis, but their function could be shifted during energy imbalance or by crosstalk with microbial metabolites in the stem cell niche. This study reports the effect of obesity and microbiota-derived short-chain fatty acids (SCFAs) on intestinal s...

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Bibliographic Details
Main Authors: Mona Farhadipour, Kaline Arnauts, Mathias Clarysse, Theo Thijs, Kathrin Liszt, Bart Van der Schueren, Laurens J. Ceulemans, Ellen Deleus, Matthias Lannoo, Marc Ferrante, Inge Depoortere
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:iScience
Subjects:
Biological sciences
Neuroscience
Behavioral neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223025944

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223025944

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