Biomarkers of histone deacetylase inhibitor activity in a phase 1 combined-modality study with radiotherapy.

Biomarkers of histone deacetylase inhibitor activity in a phase 1 combined-modality study with radiotherapy.

Following the demonstration that histone deacetylase inhibitors enhanced experimental radiation-induced clonogenic suppression, the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study, combining fractionated radiotherapy with daily vorinostat for pelvic carcinoma, was designed to evaluate both cli...

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Bibliographic Details
Main Authors: Anne Hansen Ree, Marie Grøn Saelen, Erta Kalanxhi, Ingrid H G Østensen, Kristina Schee, Kathrine Røe, Torveig Weum Abrahamsen, Svein Dueland, Kjersti Flatmark
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3934935?pdf=render

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http://europepmc.org/articles/PMC3934935?pdf=render

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