A Uniquely Stable Trimeric Model of SARS-CoV-2 Spike Transmembrane Domain

A Uniquely Stable Trimeric Model of SARS-CoV-2 Spike Transmembrane Domain

Understanding fusion mechanisms employed by SARS-CoV-2 spike protein entails realistic transmembrane domain (TMD) models, while no reliable approaches towards predicting the 3D structure of transmembrane (TM) trimers exist. Here, we propose a comprehensive computational framework to model the spike...

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Bibliographic Details
Main Authors: Elena T. Aliper, Nikolay A. Krylov, Dmitry E. Nolde, Anton A. Polyansky, Roman G. Efremov
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
structure prediction
viral fusion protein
molecular dynamics simulation
molecular hydrophobicity potential
transmembrane domain
helical trimer
Online Access:https://www.mdpi.com/1422-0067/23/16/9221

Internet

https://www.mdpi.com/1422-0067/23/16/9221

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