Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial)
Vincristine (VCR) is a frequently used chemotherapeutic agent. However, it can lead to VCR-induced peripheral neuropathy (VIPN). In this study we investigated if one-hour infusions of VCR instead of push-injections reduces VIPN in pediatric oncology patients. We conducted a multicenter randomized co...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/12/3745 |
| _version_ | 1797544878215790592 |
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| author | Mirjam Esther van de Velde Gertjan J. L. Kaspers Floor C. H. Abbink Jos W. R. Twisk Inge M. van der Sluis Cor van den Bos Marry M. van den Heuvel-Eibrink Heidi Segers Christophe Chantrain Jutte van der Werff ten Bosch Leen Willems Marleen H. van den Berg |
| author_facet | Mirjam Esther van de Velde Gertjan J. L. Kaspers Floor C. H. Abbink Jos W. R. Twisk Inge M. van der Sluis Cor van den Bos Marry M. van den Heuvel-Eibrink Heidi Segers Christophe Chantrain Jutte van der Werff ten Bosch Leen Willems Marleen H. van den Berg |
| author_sort | Mirjam Esther van de Velde |
| collection | DOAJ |
| description | Vincristine (VCR) is a frequently used chemotherapeutic agent. However, it can lead to VCR-induced peripheral neuropathy (VIPN). In this study we investigated if one-hour infusions of VCR instead of push-injections reduces VIPN in pediatric oncology patients. We conducted a multicenter randomized controlled trial in which participants received all VCR administrations through push injections or one-hour infusions. VIPN was measured at baseline and 1–5 times during treatment using Common Terminology Criteria of Adverse Events (CTCAE) and pediatric-modified Total Neuropathy Score. Moreover, data on co-medication, such as azole antifungals, were collected. Overall, results showed no effect of administration duration on total CTCAE score or ped-mTNS score. However, total CTCAE score was significantly lower in patients receiving one-hour infusions concurrently treated with azole antifungal therapy (β = -1.58; <i>p</i> = 0.04). In conclusion, generally VCR administration through one-hour infusions does not lead to less VIPN compared to VCR push injections in pediatric oncology patients. However, one-hour infusions lead to less severe VIPN compared to push-injections when azole therapy is administered concurrently with VCR. These results indicate that in children treated with VCR and requiring concurrent azole therapy, one-hour infusions might be beneficial over push injections, although larger trials are needed to confirm this association. |
| first_indexed | 2024-03-10T14:06:47Z |
| format | Article |
| id | doaj.art-54fd820ad2d540bab96fae78ed55ec22 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T14:06:47Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-54fd820ad2d540bab96fae78ed55ec222023-11-21T00:33:13ZengMDPI AGCancers2072-66942020-12-011212374510.3390/cancers12123745Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial)Mirjam Esther van de Velde0Gertjan J. L. Kaspers1Floor C. H. Abbink2Jos W. R. Twisk3Inge M. van der Sluis4Cor van den Bos5Marry M. van den Heuvel-Eibrink6Heidi Segers7Christophe Chantrain8Jutte van der Werff ten Bosch9Leen Willems10Marleen H. van den Berg11Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Oncology, 1081 HV Amsterdam, The NetherlandsEmma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Oncology, 1081 HV Amsterdam, The NetherlandsEmma Children’s Hospital, Amsterdam UMC, Amsterdam Medical Center, Pediatric Oncology, 1105 AZ Amsterdam, The NetherlandsDepartment of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The NetherlandsPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The NetherlandsPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The NetherlandsPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The NetherlandsDepartment of Pediatric Hemato-Oncology, University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Pediatrics, Clinique du MontLégia, CHC, 4000 Liège, BelgiumDepartment of Pediatric Onco-Hematology, Universitair Ziekenhuis Brussel, 1090 Brussels, BelgiumDepartment of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, 9000 Ghent, BelgiumEmma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Oncology, 1081 HV Amsterdam, The NetherlandsVincristine (VCR) is a frequently used chemotherapeutic agent. However, it can lead to VCR-induced peripheral neuropathy (VIPN). In this study we investigated if one-hour infusions of VCR instead of push-injections reduces VIPN in pediatric oncology patients. We conducted a multicenter randomized controlled trial in which participants received all VCR administrations through push injections or one-hour infusions. VIPN was measured at baseline and 1–5 times during treatment using Common Terminology Criteria of Adverse Events (CTCAE) and pediatric-modified Total Neuropathy Score. Moreover, data on co-medication, such as azole antifungals, were collected. Overall, results showed no effect of administration duration on total CTCAE score or ped-mTNS score. However, total CTCAE score was significantly lower in patients receiving one-hour infusions concurrently treated with azole antifungal therapy (β = -1.58; <i>p</i> = 0.04). In conclusion, generally VCR administration through one-hour infusions does not lead to less VIPN compared to VCR push injections in pediatric oncology patients. However, one-hour infusions lead to less severe VIPN compared to push-injections when azole therapy is administered concurrently with VCR. These results indicate that in children treated with VCR and requiring concurrent azole therapy, one-hour infusions might be beneficial over push injections, although larger trials are needed to confirm this association.https://www.mdpi.com/2072-6694/12/12/3745neurotoxicityexposurechildrencancervincristinetoxicity |
| spellingShingle | Mirjam Esther van de Velde Gertjan J. L. Kaspers Floor C. H. Abbink Jos W. R. Twisk Inge M. van der Sluis Cor van den Bos Marry M. van den Heuvel-Eibrink Heidi Segers Christophe Chantrain Jutte van der Werff ten Bosch Leen Willems Marleen H. van den Berg Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial) Cancers neurotoxicity exposure children cancer vincristine toxicity |
| title | Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial) |
| title_full | Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial) |
| title_fullStr | Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial) |
| title_full_unstemmed | Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial) |
| title_short | Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial) |
| title_sort | vincristine induced peripheral neuropathy in pediatric oncology a randomized controlled trial comparing push injections with one hour infusions the vinca trial |
| topic | neurotoxicity exposure children cancer vincristine toxicity |
| url | https://www.mdpi.com/2072-6694/12/12/3745 |
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