Atorvastatin does not protect against ischemia-reperfusion damage in cholestatic rat livers

Atorvastatin does not protect against ischemia-reperfusion damage in cholestatic rat livers

Abstract Background Extrahepatic cholestasis sensitizes the liver to ischemia/reperfusion (I/R) injury during surgery for perihilar cholangiocarcinoma. It is associated with pre-existent sterile inflammation, microvascular perfusion defects, and impaired energy status. Statins have been shown to pro...

Full description

Bibliographic Details
Main Authors: Jimme K. Wiggers, Rowan F. van Golen, Joanne Verheij, Annemiek M. Dekker, Thomas M. van Gulik, Michal Heger
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Surgery
Subjects:
Atorvastatin
Primary Biliary Cirrhosis
Cholestasis
Bile Duct Ligation
Ischemia Induction
Online Access:http://link.springer.com/article/10.1186/s12893-017-0235-9

Internet

http://link.springer.com/article/10.1186/s12893-017-0235-9

Similar Items