Membrane-bound and soluble forms of an NMDA receptor extracellular domain retain epitopes targeted in auto-immune encephalitis

Membrane-bound and soluble forms of an NMDA receptor extracellular domain retain epitopes targeted in auto-immune encephalitis

Abstract Background Anti-NMDA receptor encephalitis (ANRE) is a potentially lethal disease attributed to auto-antibodies against the N-methyl-D-aspartate receptor (NMDAR). Full recovery is possible if therapy is initiated early in the disease course. Detection of ANRE antibodies in the cerebrospinal...

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Bibliographic Details
Main Authors: Rashmi Sharma, Fetweh H. Al-Saleem, Rama Devudu Puligedda, Amy Rattelle, David R. Lynch, Scott K. Dessain
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Biotechnology
Subjects:
Anti-N-methyl-D-aspartate receptor encephalitis
ANRE
NMDA receptor
Monoclonal antibody
Autoimmunity
Antigen
Online Access:http://link.springer.com/article/10.1186/s12896-018-0450-1

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http://link.springer.com/article/10.1186/s12896-018-0450-1

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