Host serine protease ACOT2 assists DENV proliferation by hydrolyzing viral polyproteins

Host serine protease ACOT2 assists DENV proliferation by hydrolyzing viral polyproteins

ABSTRACTDengue fever is a mosquito-borne tropical disease caused by the dengue virus (DENV). The replication of DENV relies on the processing of its genome-encoded polyprotein by both viral protease NS3 (NS3pro) and host proteases. However, the impact of host proteases on DENV proliferation is not w...

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Bibliographic Details
Main Authors: Sen Ma, Sai Shi, Binghong Xu, Meijun Liu, Lei Xie, Yang Su, Jiachen Li, Qinqin Liang, Sheng Ye, Yaxin Wang
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mSystems
Subjects:
ABPP
DENV
ACOT2
serine protease
virus replication
Online Access:https://journals.asm.org/doi/10.1128/msystems.00973-23

Internet

https://journals.asm.org/doi/10.1128/msystems.00973-23

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