Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

As part of a drug discovery effort to identify potent inhibitors of NaV1.7 for the treatment of pain, we observed that inhibitors produced unexpected cardiovascular and respiratory effects in vivo. Specifically, inhibitors administered to rodents produced changes in cardiovascular parameters and res...

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Bibliographic Details
Main Authors: Rebecca M. Klein, Mark E. Layton, Hillary Regan, Christopher P. Regan, Yuxing Li, Tracey Filzen, Matt Cato, Michelle K. Clements, Jixin Wang, Raul Sanoja, Thomas J. Greshock, Anthony J. Roecker, Joseph E. Pero, Ron Kim, Christopher Burgey, Christopher T. John, Ying-Hong Wang, Neetesh Bhandari, Arie Struyk, Richard L. Kraus, Darrell A. Henze, Andrea K. Houghton
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Channels
Subjects:
Sodium channel inhibitor
respiration
selectivity
phrenic nerve
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2022.2122309

Internet

https://www.tandfonline.com/doi/10.1080/19336950.2022.2122309

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