Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota

Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota

Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan (5-HTP) → ser...

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Bibliographic Details
Main Authors: Zheng-Wei Zhang, Chun-Sheng Gao, Heng Zhang, Jian Yang, Ya-Ping Wang, Li-Bin Pan, Hang Yu, Chi-Yu He, Hai-Bin Luo, Zhen-Xiong Zhao, Xin-Bo Zhou, Yu-Li Wang, Jie Fu, Pei Han, Yu-Hui Dong, Gang Wang, Song Li, Yan Wang, Jian-Dong Jiang, Wu Zhong
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Depression
Morinda officinalis oligosaccharides
Gut microbiota
Tryptophan hydroxylase
5-Hydroxytryptophan decarboxylase
5-Hydroxytryptophan
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522000983

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http://www.sciencedirect.com/science/article/pii/S2211383522000983

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