Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity <it>in vivo</it>

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity <it>in vivo</it>

<p>Abstract</p> <p>Background</p> <p>Elevated <it>SNCA </it>gene expression and intracellular accumulation of the encoded α-synuclein (aSyn) protein are associated with the development of Parkinson disease (PD). To date, few enzymes have been examined for th...

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Main Authors: Cullen Valerie, Lindfors Maria, Ng Juliana, Paetau Anders, Swinton Erika, Kolodziej Piotr, Boston Heather, Saftig Paul, Woulfe John, Feany Mel B, Myllykangas Liisa, Schlossmacher Michael G, Tyynelä Jaana
Format: Article
Language:English
Published: BMC 2009-02-01
Series:Molecular Brain
Online Access:http://www.molecularbrain.com/content/2/1/5

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http://www.molecularbrain.com/content/2/1/5

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