Structure and Assembly of the PI3K-like Protein Kinases (PIKKs) Revealed by Electron Microscopy

Structure and Assembly of the PI3K-like Protein Kinases (PIKKs) Revealed by Electron Microscopy

The phosphatidylinositol 3-kinase-like kinases (PIKKs) are large serine-threonine protein kinases with a catalytic domain homologous to the phosphatidylinositol 3-kinase (PI3K). All PIKK family members share a general organization comprising a conserved C-terminus that contains the PI3K domain, whic...

Full description

Bibliographic Details
Main Authors: Angel Rivera-Calzada, Andrés López-Perrote, Roberto Melero, Jasminka Boskovic, Hugo Muñoz-Hernández, Fabrizio Martino, Oscar Llorca
Format: Article
Language:English
Published: AIMS Press 2015-03-01
Series:AIMS Biophysics
Subjects:
ATM
ATR
DNA-PKcs
mTOR
SMG1
TRRAP
PIKK
RuvBL1
RuvBL2
R2TP
3D-electron microscopy
Online Access:http://www.aimspress.com/biophysics/article/279/fulltext.html

Internet

http://www.aimspress.com/biophysics/article/279/fulltext.html

Similar Items