Parallel purification of microscale libraries via automated solid phase extraction

Parallel purification of microscale libraries via automated solid phase extraction

High-throughput experimentation (HTE) has become more widely utilized in drug discovery for rapid reaction optimization and generation of large synthetic compound arrays. While this has accelerated medicinal chemistry design, make, test (DMT) iterations, the bottleneck of purification persists, cons...

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Bibliographic Details
Main Authors: Michael Wleklinski, Paige M. Carpenter, Kevin D. Dykstra, Anthony Donofrio, Timothy Nowak, Shane W. Krska, Ronald D. Ferguson
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:SLAS Technology
Subjects:
HTE
Parallel purification
Automation
Parallel synthesis
Analytical
Online Access:http://www.sciencedirect.com/science/article/pii/S2472630324000086

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http://www.sciencedirect.com/science/article/pii/S2472630324000086

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