Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity

Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity

Summary: During acute malaria, most individuals mount robust inflammatory responses that limit parasite burden. However, long-lived sterilizing anti-malarial memory responses are not efficiently induced, even following repeated Plasmodium exposures. Using multiple Plasmodium species, genetically mod...

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Bibliographic Details
Main Authors: Angela D. Pack, Patrick V. Schwartzhoff, Zeb R. Zacharias, Daniel Fernandez-Ruiz, William R. Heath, Prajwal Gurung, Kevin L. Legge, Chris J. Janse, Noah S. Butler
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
Plasmodium
malaria
hemozoin
humoral immunity
germinal center
T follicular helper
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721010202

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http://www.sciencedirect.com/science/article/pii/S2211124721010202

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