Inactivation of NLRP3 inflammasome by dephosphorylation at Serine 658 alleviates glial inflammation in the mouse model of Parkinson’s disease

Inactivation of NLRP3 inflammasome by dephosphorylation at Serine 658 alleviates glial inflammation in the mouse model of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is a leading neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, contributing to considerable disability worldwide. Current treatments offer only symptomatic relief, highlighting the need for novel therapeutic strateg...

Full description

Bibliographic Details
Main Authors: Rong-Xin Zhu, Rui-Xue Han, Yue-Han Chen, Lei Huang, Ting Liu, Jingwei Jiang, Cong Wang, Lei Cao, Yang Liu, Ming Lu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Neurodegeneration
Subjects:
NLRP3 inflammasome
Phosphorylation
Serine 658
Inflammation
Parkinson’s disease
Online Access:https://doi.org/10.1186/s13024-025-00818-z

Internet

https://doi.org/10.1186/s13024-025-00818-z

Similar Items