Carboxypeptidase A4 negatively regulates HGS-ETR1/2-induced pyroptosis by forming a positive feedback loop with the AKT signalling pathway
Abstract Pyroptosis, a mode of inflammatory cell death, has recently gained significant attention. However, the underlying mechanism remains poorly understood. HGS-ETR1/2 is a humanized monoclonal antibody that can bind to DR4/5 on the cell membrane and induce cell apoptosis by activating the death...
Main Authors: | Luoling Wang, Rilin Deng, Shuishun Chen, Renyun Tian, Mengmeng Guo, Zihao Chen, Yingdan Zhang, Huiyi Li, Qian Liu, Songqing Tang, Haizhen Zhu |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2023-12-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-023-06327-5 |
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