A human protein interaction network shows conservation of aging processes between human and invertebrate species.

We have mapped a protein interaction network of human homologs of proteins that modify longevity in invertebrate species. This network is derived from a proteome-scale human protein interaction Core Network generated through unbiased high-throughput yeast two-hybrid searches. The longevity network i...

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Bibliographic Details
Main Authors: Russell Bell, Alan Hubbard, Rakesh Chettier, Di Chen, John P Miller, Pankaj Kapahi, Mark Tarnopolsky, Sudhir Sahasrabuhde, Simon Melov, Robert E Hughes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2657003?pdf=render