Anticonvulsant and ameliorative effects of pioglitazone on cognitive deficits, inflammation and apoptosis in the hippocampus of rat pups exposed to febrile seizure

Anticonvulsant and ameliorative effects of pioglitazone on cognitive deficits, inflammation and apoptosis in the hippocampus of rat pups exposed to febrile seizure

Objective(s): Pioglitazone (PGZ), a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, has significant neuroprotective effects and has been reported to regulate inflammatory processes.Materials and Methods: We evaluated the effects of PGZ on febrile seizure (FS) in rat pups. Three gr...

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Bibliographic Details
Main Authors: Hussein Hussein, Ali Moghimi, Ali Roohbakhsh
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2019-03-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Apoptosis
Febrile seizure
Hippocampus
Inflammation
Memory
Pioglitazone
Online Access:http://ijbms.mums.ac.ir/article_12195_0158855c3f687bdebb9ddaeb1c47e94a.pdf

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