Alpha-Synuclein Aggregation Pathway in Parkinson’s Disease: Current Status and Novel Therapeutic Approaches

Alpha-Synuclein Aggregation Pathway in Parkinson’s Disease: Current Status and Novel Therapeutic Approaches

Following Alzheimer’s, Parkinson’s disease (PD) is the second-most common neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile, and massive social costs worldwide. Despite this, no disease-modifying therapy is available. PD is tightly associated with α-synuclein (...

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Bibliographic Details
Main Authors: Marija Vidović, Milena G. Rikalovic
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
α-synuclein oligomers and fibrils
disaggregators
high throughput anti-aggregation drug screening
intrinsically disordered proteins
protein misfolding
rationally designed peptidomimetics
Online Access:https://www.mdpi.com/2073-4409/11/11/1732

Internet

https://www.mdpi.com/2073-4409/11/11/1732

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