Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning?

Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning?

Earlier studies revealed the presence of cysteine persulfide (CysSSH) and related polysulfide species in various mammalian tissues. CysSSH has both antioxidant and oxidant properties, modulates redox-dependent signal transduction and has been shown to mitigate oxidative stress. However, its function...

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Bibliographic Details
Main Authors: Kayleigh Griffiths, Tomoaki Ida, Masanobu Morita, Reece J. Lamb, Jordan J. Lee, Michael P. Frenneaux, Jon M. Fukuto, Takaaki Akaike, Martin Feelisch, Melanie Madhani
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Redox Biology
Subjects:
Cysteine persulfide
Hydrogen sulfide
Ischaemia-reperfusion injury
Lipid peroxidation
Hypoxia
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172300006X

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http://www.sciencedirect.com/science/article/pii/S221323172300006X

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