Isothiocyanates as Tubulin Polymerization Inhibitors—Synthesis and Structure–Activity Relationship Studies

Isothiocyanates as Tubulin Polymerization Inhibitors—Synthesis and Structure–Activity Relationship Studies

Among the various substances that interfere with the microtubule formation process, isothiocyanates (ITCs) are the group of compounds for which the binding mode and mechanism of action have not yet been explained. To better understand the structure–activity relationship of tubulin-isothiocyanate int...

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Bibliographic Details
Main Authors: Renata Grzywa, Mateusz Psurski, Anna Gajda, Tadeusz Gajda, Łukasz Janczewski
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
isothiocyanates
microtubules
anticancer activity
tubulin polymerization inhibitors
α tubulin
β tubulin
Online Access:https://www.mdpi.com/1422-0067/24/18/13674

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https://www.mdpi.com/1422-0067/24/18/13674

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