GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities

GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities

Shank3 is an excitatory postsynaptic scaffolding protein implicated in multiple brain disorders, including autism spectrum disorders (ASD) and Phelan-McDermid syndrome (PMS). Although previous neurobiological studies on Shank3 and Shank3-mutant mice have revealed diverse roles of Shank3 in the regul...

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Bibliographic Details
Main Authors: Taesun Yoo, Heejin Cho, Jiseok Lee, Haram Park, Ye-Eun Yoo, Esther Yang, Jin Yong Kim, Hyun Kim, Eunjoon Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
autism
Phelan-McDermid syndrome
Shank3
striatum
social interaction
repetitive behavior
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00341/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00341/full

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