Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets

Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets

Abstract Background Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with poor treatment options. However, most mouse models of COPD produce a primarily emphysematous disease not recapitulating clinically meaningful COPD features like chronic bronchitis. Methods Wild-type f...

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Bibliographic Details
Main Authors: Shah S. Hussain, Yvonne J. K. Edwards, Emily Falk Libby, Denise Stanford, Stephen A. Byzek, Don D. Sin, Merry-Lynn McDonald, S. Vamsee Raju, Steven M. Rowe
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Respiratory Research
Subjects:
COPD
Chronic bronchitis
Ferret model
Gene expression
Cigarette smoke
Online Access:https://doi.org/10.1186/s12931-022-02198-0

Internet

https://doi.org/10.1186/s12931-022-02198-0

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