Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects.
Shp2 is a cytoplasmic protein-tyrosine phosphatase that is essential for normal development. Activating and inactivating mutations have been identified in humans to cause the related Noonan and LEOPARD syndromes, respectively. The cell biological cause of these syndromes remains to be determined. We...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-12-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2151089?pdf=render |