Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1

Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1

Abstract Background Amyotrophic lateral sclerosis (ALS) is a complex, late-onset, neurodegenerative disease with a genetic contribution to disease liability. Genome-wide association studies (GWAS) have identified ten risk loci to date, including the TNIP1/GPX3 locus on chromosome five. Given associa...

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Main Authors: Restuadi Restuadi, Frederik J. Steyn, Edor Kabashi, Shyuan T. Ngo, Fei-Fei Cheng, Marta F. Nabais, Mike J. Thompson, Ting Qi, Yang Wu, Anjali K. Henders, Leanne Wallace, Chris R. Bye, Bradley J. Turner, Laura Ziser, Susan Mathers, Pamela A. McCombe, Merrilee Needham, David Schultz, Matthew C. Kiernan, Wouter van Rheenen, Leonard H. van den Berg, Jan H. Veldink, Roel Ophoff, Alexander Gusev, Noah Zaitlen, Allan F. McRae, Robert D. Henderson, Naomi R. Wray, Jean Giacomotto, Fleur C. Garton
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Genome Medicine
Subjects:
Motor neurone disease
MND
Genome-wide association study
Computational biology
Zebrafish
Neurodegenerative diseases
Online Access:https://doi.org/10.1186/s13073-021-01006-6

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https://doi.org/10.1186/s13073-021-01006-6

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