Prenatal folic acid and vitamin B12 imbalance alter neuronal morphology and synaptic density in the mouse neocortex

Abstract Previous reports have provided evidence that insufficient or excessive maternal folic acid (FA) intake during pregnancy can alter neurodevelopment of the offspring by modulating prenatal neurogenesis. Furthermore, our earlier work in a mouse model confirmed long-term structural changes at t...

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Bibliographic Details
Main Authors: Lyvin Tat, Noemi Cannizzaro, Zachary Schaaf, Shailaja Racherla, Teodoro Bottiglieri, Ralph Green, Konstantinos S. Zarbalis
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05492-9